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Health News: An HIV- Positive Man Died After His Parasitic Tapeworm Got Cancer

Health News: An HIV- Positive Man Died After His Parasitic Tapeworm Got Cancer

An HIV-positive Colombian man has died of cancer that began inside his tapeworm. His tumors were not made up of his own cells, but those of the parasitic worm that invaded his gut. This rare and unique situation is thought to be the first known to medicine whereby tumors have developed as a result of parasite-derived cancerous cells having spread and taken hold throughout a human host.

Described in the New England Journal of Medicine, the patient was a 41-year-old man who, back in early 2013, had been suffering fatigue, a fever, cough and weight loss for several months. He was diagnosed with HIV seven years earlier but did not take his medication. Consequently, his white blood cell (CD4) count was dangerously low and blood samples were loaded with virus particles. Fecal analysis revealed that he was also infected with the dwarf tapeworm Hymenolepis nana.

The patient was then given a CT scan which revealed that his lungs were riddled with tumors, ranging in size from 0.4 to 4.4 centimeters (0.16 to 1.7 inches) in size. His liver and adrenal glands were also infected. He was given biopsies at the time and sent home with both anti-HIV and anti-tapeworm drugs, but his condition worsened so further samples were taken and sent off to the CDC for analysis.

Health News:  An HIV- Positive Man Died After His Parasitic Tapeworm Got Cancer

This is where things got a little bit weird. The cells were clearly cancerous – they were invasive, grew rapidly and in a crowded, disordered manner, and all looked the same. But they were tiny, roughly ten times smaller than would have been expected; far too small to be considered a human cell. Baffled, scientists subjected them to a bounty of tests, which eventually revealed the tumor cells contained H. nana DNA. Unfortunately, it was too late for the patient, who died just 72 hours after the discovery was made.

Analysis of the tumor cells’ worm DNA when compared with a reference genome of an otherwise normal worm also revealed something quite striking. “Three of the identified genes that were ‘broken,’ or mutated, have already been implicated in other forms of human cancer,” study author Dr Peter Olson told IFLScience. “If they mutate in humans, they can lead to a cell becoming cancerous. That’s never really been shown, that sort of commonality between becoming malignant in a human cell line and an invertebrate cell line.”

 

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